DMSO groups had significantly reduced numbers of degenerating neurons compared to the saline-treated group. We conclude that DMSO is a viable neuroprotective agent against secondary cell death in traumatic brain injury. Di Giorgio AM. Dimethly sulphoxide provides neuroprotection in a traumatic brain injury model. Restor Neurol Neurosci. 2008;26(6):501-7. PMID:19096138.
Ten patients with closed head trauma & elevated intracranial pressure (ICP) ranging from 40-127 mm Hg were treated with intravenous DMSO every 6h for 1-10 days. Four patients received DMSO & intermittent oxygen. All patients showed a reduction of ICP after 24h and 7 had normal ICP after 6 days of treatment. Two patients died of their injuries. Neurological assessment at the time of discharge showed 2 patients with severe neurological deficits & 6 patiencts with mild to no deficit. After 3 month followup, 1 patient remained severely impaired & 7 patients showed mild to no deficit. It appears that intravenous DMSO can rapidly reduce elevated ICP in severe closed-head injury & that it improves neurological outcome. Karaca M. Dimethly sulphoxide lowers ICP after closed head trauma. Eur J Clin Pharmacol. 1991;40(1):113-4. PMID:2060538.
Mice were subjected to moderate (800g/cm) force or severe (900g/cm) force head injury and treated 5 minutes later with intravenous (1)fructose, (2)DMSO, (3)DMSO & fructose, (4)nontreated. Sensory-motor evaluations 1 and 2 hours after 800g/cm showed significant protection of motor function with DMSO & fructose, but not with either agent alone. Evaluation of mice following a severe 900g/cm force injury demonstrated significant survival after treatment with DMSO & fructose but not with either of these agents alone. Parkinson D.Treatment of head injury in mice, using a fructose 1,6-diphosphate and dimethyl sulfoxide combination. Neurosurgery. 1996 Jan;38(1):232. PMID:8747980.
40 Monkeys were subjected to acute head injury with compression of the brain. A critical endpoint in the compression was to inject either saline, urea or DMSO. All saline animals died. Ten of the 15 urea-treated animals survived, while 14 of the 15 DMSO-injected monkeys survived. In addition, neurological defects seen in the surviving animals were less evident in DMSO-treated monkeys when compared to those that received urea. De la Torre JC. Dimethyl sulfoxide in the treatment of experimental brain compression.
Neurosurg. 1973 Mar;38(3):345-54. PMID:4197201.
Directions for Use: Immediately after injury take 15ml (tbsp) (10500mg) of
70% DMSO and 30% water in a glass of fresh fruit juice (fructose) 3 or 4 times a day. However if possible get a GP to administer to you intravenously.