Dupuytren's is a thickening and contracting of fibrous tissue under the skin that results in fingers closing into a permanent claw. Fibrous tissue contains collagen and we show below that DMSO softens collagen.

The authors recorded that topical DMSO in man exerted a significant effect on diseased collagen under the skin in human fibrosis but did not appear to change the equilibrium of collagen metabolism in normal tissue. Gries, G. The effect of dimethyl sulfoxide on the components of connective tissue (Clinical and experimental investigations). Ann NY Acad Sci. 1967 Mar 15;141(1):630-7. PMID:4227302.

Scar tissue in man before and after DMSO therapy show improvement towards normal. Engle MF. Indications and contraindications for the use of DMSO in clinical dermatology. Ann NY Acad Sci. 1967 Mar 15;141(1):638-45. PMID:5233139.

DMSO is one of the stars of any broad-base Dupuytren's Contracture program. It has some great science and research behind it, and it just makes a lot of sense to apply such an effective product directly to the problem area of the hand. In addition, DMSO can be used to enhance absorption of copper and vitamin E into the scar tissue area – both of which are also critically important to any Dupuytren's Contracture program. Dupuytren's Contracture Institute. 432 East Northwest Highway
Palatine, IL  60074. Toll Free - (877) 878-8188. www.dupuytrens-contracture.com

Directions for Use: First apply one or more primary substance (vitamin E and/or ionic copper) to the skin, then apply DMSO. Allow to penetrate the skin for full benefit (about 30 minutes), as determined by complete drying. Further to this it is recommended that enzymes (Neprinol) and MSM (oxidised DMSO) are taken orally.