42 patients were treated for scleroderma. Initially, DMSO was applied topically to affected areas in concentrations ranging from 30% to 60%. Subsequently, the concentration was increased to 70% and, in some cases, to 100%. Usually, the DMSO was applied three times daily for approximately three months, then twice daily, until softening of the skin and the range of motion were nearly normal, and then reduced to one application daily. The total dose of DMSO applied to the entire body was estimated at 60 to 100 gm daily for periods ranging from two to three weeks.

In 42 patients, 26 showed good or excellent improvement and 16 showed fair or poor response to therapy. Of the 26 with good to excellent response, three have discontinued therapy after one year because skin changes, range of joint motion, grip strength, and histologic changes have returned to normal. In each of these cases, improvement has been maintained six months after cessation of treatment. It is our opinion that they have gone into a spontaneous remission while undergoing treatment. The other 23 patients are maintaining good to excellent response while continuing to use DMSO, mainly in the form of hand soaks and topical application to the forearms. Scherbel AL. Further observations on the effect of dimethyl sulfoxide in patients with generalized scleroderma. (Progressive systemic sclerosis). Ann NY Acad Sci. 1967 Mar 15;141(1):613-29. PMID:5232269.

Dimethyl sulfoxide (DMSO) has been used since 1974 in the complex cure of systemic scleroderma in the Institute of Rheumatology AMS USSR. In a double blind trial, applying 50% solution of DMSO for 30-40 mins, we observed convincing positive results. Murav'ev IuV. Effectiveness of long-term use of dimethyl sulfoxide in the complex treatment of patients with systemic scleroderma. Ter Arkh. 1985;57(8):125-7. PMID:3906994.

Directions for Use: As a minimum - Apply 4 to 6 sprays of 70% DMSO and 30% Aloe Vera morning and night to the areas of skin thickening and rub in well. After application rub in a good quality moisturiser like "Natural Instinct" Natural Body Lotion to help improve skin condition.